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简介:
纳米金是指金的粒径為(wèi)1-100nm之间的粒子,分(fēn)散在水溶液或有(yǒu)机溶液中。纳米金在一些特定的晶面上存在着表面電(diàn)子态,其费米能(néng)级恰好位于體(tǐ)能(néng)带结构沿该晶向的禁带中,形成只能(néng)平行于表面方向的二维電(diàn)子云。这是纳米金的表面效应,量子效应和宏观量子隧道效应的物(wù)理(lǐ)基础。纳米金随其直径由大而小(xiǎo)呈现深黄色至黑色,纳米金在520nm左右可(kě)见光谱范围之间有(yǒu)一个金的横向伸缩振动吸收峰,吸收波長(cháng)随金粒子粒径表达而增加,当有(yǒu)纳米金棒生成时,在近红外处就会出现吸收峰。当粒径从小(xiǎo)到大变化时,溶液的颜色这一次表现為(wèi)深黄色,粉红色,酒红色,深红色,蓝色的变化。随着金纳米粒子的聚沉,吸收峰会变宽。胶體(tǐ)金的性质主要取决于纳米金粒子的粒径及其表面修饰。
球形金纳米粒子的部分(fēn)属性:
粒径大小(xiǎo) (nm) | 浓度 (mg/ml) | 粒子数(Particles/mL) | SPR Wavelength (nm) |
2 | 0.1 | 1.5x1014 | ~510 |
3 | 0.1 | 1.2x1014 | 512~515 |
5 | 0.1 | 5.0x1013 | 515~520 |
10 | 0.1 | 5.7x1012 | 515~520 |
15 | 0.1 | 1.4x1012 | 525 |
20 | 0.1 | 7.0x1011 | 527 |
30 | 0.1 | 2.0x1011 | ~530 |
40 | 0.1 | 9.0x1010 | ~535 |
50 | 0.1 | 4.5x1010 | ~540 |
80 | 0.1 | 2.6x1010 | ~553 |
100 | 0.1 | 1.1x1010 | ~572 |
150 | 0.1 | 5.6x109 | -- |
200 | 0.1 | 1.7x109 | -- |
纳米金棒的部分(fēn)属性:
長(cháng)径比 | 直径 (nm) | 浓度 (mg/ml) | SPR Wavelength (nm) | 颜色 |
2.0 | 40 | 0.1 | 660 | 蓝色 |
2.5 | 30 | 0.1 | 657 | 蓝色 |
3.0 | 30 | 0.1 | 700 | 棕黄色 |
3.2 | 25 | 0.1 | 720 | 棕红色 |
3.5 | 23 | 0.1 | 805 | 酒红色 |
4.0 | 29 | 0.1 | 760 | 酒红色 |
4.3 | 25 | 0.1 | 830 | 酒红色 |
5.0 | 20 | 0.1 | 960 | 蓝色 |
PEG化金纳米粒子可(kě)以避免纳米材料在合成过程中所吸附的表面活性剂(CTAB)所造成的生物(wù)毒性,进一步提高其水溶性、生物(wù)相容性和體(tǐ)内循环时间,从而获得更加良好的诊断、成像和光热治疗的能(néng)力。通过PEG的官能(néng)团-COOH,-NH2,-FA,-Biotin等活性基团连接生物(wù)分(fēn)子,利用(yòng)生物(wù)分(fēn)子的特异性识别作用(yòng),使得金纳米粒子表面偶联特异性分(fēn)子实现对肿瘤的主动靶向诊断和治疗研究。
PEG化纳米金棒的部分(fēn)属性:
長(cháng)径比 | 浓度(mg/ml) | SPR Wavelength (nm) |
2.0 | 0.1 | 680 |
2.5 | 0.1 | 680 |
3.0 | 0.1 | 720 |
3.2 | 0.1 | 735 |
3.5 | 0.1 | 820 |
4.0 | 0.1 | 780 |
4.3 | 0.1 | 855 |
5.0 | 0.1 | 980 |
经PEG修饰后纳米金棒表面会带负電(diàn)荷
(zeta-AuNRs-CTAB)
(zeta-AuNRs-PEG)
1:聚乙二醇修饰的球形纳米金产品:
Gold Nanoparticles,Au-S-PEG-X(末端基团)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000
X末端基团:NH2/COOH/MAL/NHS/BIOTIN/SH/N3/Folate/OPSS/FITC/RB/DSPE/Alkyne
SGA/Silane/OH/PLGA/PLA/PCL/CH3
粒径:5/10/15/20/30/40/50/60/70/80/90/100nm
2:聚乙二醇修饰的纳米金棒(AuNRs)产品:
Gold Nanorods,Au-S-PEG-X(末端基团)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000
X末端基团:NH2/COOH/MAL/NHS/BIOTIN/SH/N3/Folate/OPSS/FITC/RB/DSPE/Alkyne
SGA/Silane/OH/PLGA/PLA/PCL/CH3
聚乙二醇修饰的纳米金及纳米金棒的价格表:
Gold Nanoparticles,Au-S-PEG-Methoxy
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 ,粒径:5nm-100nm
低浓度:0.1mg/ml 2800元/25ml, 4200元/50ml
高浓度:0.5mg/ml 4200元/25ml, 6500元/50ml
Gold Nanoparticles,Au-S-PEG-Amine(NH2)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-Carboxyl(COOH)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-Maleimide(MAL)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-NHS (NHS)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-Biotin (Biotin)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-Azide (N3)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-Folic acid (FA)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-OPSS (OPSS)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG- Fluorescein (FITC)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 5200元/25ml, 7800元/50ml
高浓度:0.5mg/ml 7800元/25ml, 9000元/50ml
Gold Nanoparticles,Au-S-PEG-RhodamineB (RB)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 5200元/25ml, 7800元/50ml
高浓度:0.5mg/ml 7800元/25ml, 9000元/50ml
Gold Nanoparticles,Au-S-PEG-DSPE (DSPE)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 5200元/25ml, 7800元/50ml
高浓度:0.5mg/ml 7800元/25ml, 9000元/50ml
Gold Nanoparticles,Au-S-PEG-Cholesterol (CHOL)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 5200元/25ml, 7800元/50ml
高浓度:0.5mg/ml 7800元/25ml, 9000元/50ml
Gold Nanoparticles,Au-S-PEG-Alkyne(ALK)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-OH(OH)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-OH(OH)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-Silane(Silane)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-PLGA(PLGA)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 6500元/25ml, 8300元/50ml
高浓度:0.5mg/ml 8300元/25ml, 9500元/50ml
Gold Nanoparticles,Au-S-PEG-PLA(PLA)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 6500元/25ml, 8300元/50ml
高浓度:0.5mg/ml 8300元/25ml, 9500元/50ml
Gold Nanoparticles,Au-S-PEG-PCL(PCL)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 粒径:5nm-100nm
低浓度:0.1mg/ml 6500元/25ml, 8300元/50ml
高浓度:0.5mg/ml 8300元/25ml, 9500元/50ml
Gold Nanorods,Au-S-PEG-Methoxy
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-Amine(NH2)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-Carboxyl (COOH)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-Maleimide (MAL)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-NHS (NHS)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-Biotin (Biotin)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-Azide (N3)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-Folic acid (FA)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 4900元/25ml, 7500元/50ml
高浓度:0.5mg/ml 7250元/10ml, 9700元/25ml
Gold Nanorods,Au-S-PEG-OPSS (OPSS)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG- Fluorescein (FITC)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 4900元/25ml, 7500元/50ml
高浓度:0.5mg/ml 7250元/10ml, 9700元/25m
Gold Nanorods,Au-S-PEG-RhodamineB (RB)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 4900元/25ml, 7500元/50ml
高浓度:0.5mg/ml 7250元/10ml, 9700元/25m
Gold Nanorods,Au-S-PEG-DSPE (DSPE)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 4900元/25ml, 7500元/50ml
高浓度:0.5mg/ml 7250元/10ml, 9700元/25m
Gold Nanorods,Au-S-PEG-Cholesterol (CHOL)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 4900元/25ml, 7500元/50ml
高浓度:0.5mg/ml 7250元/10ml, 9700元/25m
Gold Nanorods,Au-S-PEG-Alkyne(ALK)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-OH(OH)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-Silane(Silane)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 3800元/25ml, 5500元/50ml
高浓度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-PLGA(PLGA)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 6800元/25ml, 9500元/50ml
高浓度:0.5mg/ml 9200元/10ml, 13000元/25ml
Gold Nanorods,Au-S-PEG-PLA(PLA)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 6800元/25ml, 9500元/50ml
高浓度:0.5mg/ml 9200元/10ml, 13000元/25ml
Gold Nanorods,Au-S-PEG-PCL(PCL)
PEG分(fēn)子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低浓度:0.1mg/ml 6800元/25ml, 9500元/50ml
高浓度:0.5mg/ml 9200元/10ml, 13000元/25ml
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